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Polynucleotides have become one of the fastest growing regenerative treatments in aesthetics over the past few years, and the reason is simple. Clients are moving away from obvious enhancements and towards treatments that genuinely improve skin quality. We are seeing a shift from volume to vitality, from quick fixes to longevity, and polynucleotides sit right at the center of that change.
Polynucleotides are long chains of purified DNA fragments, most commonly derived from salmon. When injected into the skin, they work at a cellular level by stimulating fibroblasts, the cells responsible for producing collagen and elastin. This means we are not simply filling or freezing, we are encouraging the skin to repair itself. Over time this improves hydration, elasticity, skin density and overall resilience. The result is healthier, stronger skin that behaves better naturally rather than skin that simply looks temporarily altered.
Because polynucleotides are regenerative rather than volumising, the results are subtle and progressive. This is not an overnight transformation and it is not designed to be. Most clients require a course of two to three sessions to achieve optimal results, as collagen stimulation and tissue repair take time. What makes this treatment so exciting is that it improves the behaviour of the skin itself. Inflammation reduces, hydration improves and the skin gradually appears smoother, brighter and more resilient in a way that looks completely natural.
There is often confusion between injectable polynucleotides and topical PDRN skincare products. While PDRN is a fragment of polynucleotide and can offer surface hydration and soothing benefits when applied topically, it cannot penetrate to the same depth as an injectable treatment. The skin barrier prevents larger molecules from reaching the dermis, which is why true regenerative stimulation requires precise placement beneath the surface. Topical products can absolutely support and maintain skin health, but they do not replace injectable polynucleotide therapy when it comes to structural collagen stimulation.
The treatments I offer are pure polynucleotide formulations rather than diluted blends or topical alternatives. The facial protocol contains 50mg of polynucleotides, delivering a strong regenerative stimulus across the full face to improve density, elasticity and overall skin quality. Alongside this, the dedicated eye treatment contains 30mg and is specifically designed for the delicate periocular region where skin is thinner, more fragile and prone to dark circles, fine lines and crepey texture. Treating the eye area properly rather than as an afterthought makes a significant difference to overall facial rejuvenation.
Polynucleotide treatments are particularly beneficial for ageing skin, sensitized skin, acne-scarred skin and areas affected by post-inflammatory damage. They are also ideal for clients who want natural-looking rejuvenation without adding volume. Because they are derived from fish DNA, they are not suitable for anyone with a fish allergy, and medical consultation is always essential before treatment, particularly during pregnancy or when managing complex medical conditions.
Aesthetics is evolving. The future is not about looking different, it is about looking well. It is about supporting the skin at a cellular level so it functions better, repairs better and ages more intelligently. Polynucleotides represent a move towards regenerative medicine within aesthetics, where the focus is on strengthening, repairing and future-proofing the skin rather than masking concerns.
For clients wanting a comprehensive regenerative approach, combining both the 50mg face protocol and the 30mg eye treatment allows us to treat the skin holistically, supporting collagen stimulation across the entire facial structure while also strengthening the most delicate areas. It is an intelligent, forward-thinking treatment plan designed around long-term skin health.
If you are curious whether polynucleotides are suitable for your skin, a consultation is always the first step. Regeneration works best when it is tailored correctly.